Passive smoking can increase platelet activation in the blood
London:Passive smoking can increase platelet activation in healthy people leading to formation of blood clots which can damage many organs including the kidneys, heart and brain.
Platelet activation is indicated by Mean platelet volume (MPV) that is increased in acute thrombotic events. In thrombotic events, microscopic clots are formed in the small blood vessels.
Lactate can accumulate in the blood when the supply of oxygen to blood cells is limited. For the study, 55 healthy nonsmoker volunteers, 30 per cent males among them were prospectively enrolled.
Blood samples were taken at baseline and after spending one an hour in a smoking room to measure MPV and lactate levels.
Researchers also measured levels of COHb (formed when carbon monoxide (CO) binds with hemoglobin (Hb) in red blood
cells).The blood levels of all three parameters were statistically higher after subjects were exposed to passive smoking.
“These results show that passive smoking increases platelet activation and increases CO and lactate levels in the
blood,” Dr Mehmet G Kaya said in a statement.Researchers found significant correlations between MPV and COHb levels.
“Previous studies have suggested that the chemicals in cigarette smoke, especially nicotine and CO, increase
platelet-activating factor. The correlations found in our study suggest that the CO in cigarette smoke also increases
MPV levels. It is likely that lactate levels increased because oxygen levels in the blood dropped as CO increased,” Kaya added.
“We have shown that 1 hour exposure to passive smoking increases platelet activation, which could be the mechanism by
which it contributes to increased risk of thrombotic events in healthy people,” he said.
The research was presented at the European Society of Cardiology (ESC) Congress 2012.