Acute Myeloid Leukemia: From Fatigue To Fever, The Subtle Symptoms To Know

June 29, 2025: Acute Myeloid Leukemia (AML), a fast-progressing cancer of the blood and bone marrow, doesn’t always begin with dramatic symptoms. According to oncologists, the disease often starts with subtle changes that are commonly mistaken for routine health issues.

Fatigue, persistent low-grade fever, frequent minor infections, or unusually pale skin are some of the earliest signs that can point to AML. Because these symptoms are non-specific and can be linked to common ailments, they are often overlooked until the disease has progressed significantly.

“Many patients come in thinking they have the flu or are simply exhausted due to work or stress,” says Dr. Aarti Sharma, a hematologist. “By the time we investigate further, their blood counts are dangerously low.”

AML affects the bone marrow’s ability to produce healthy blood cells, which is why early signs typically involve symptoms related to anemia, increased susceptibility to infections, and clotting issues.

Other warning signs can include easy bruising or bleeding, shortness of breath, and unintentional weight loss. Medical professionals advise that if these symptoms persist for more than a few weeks—especially in combination—a complete blood count (CBC) test should be done promptly.

Early diagnosis is crucial, as AML progresses rapidly and can become life-threatening within weeks if left untreated. Awareness and timely medical consultation can significantly improve treatment outcomes.

Health experts emphasize the importance of not ignoring ongoing fatigue or unusual physical changes, even if they seem minor at first.